Below is a list of all Senators up for reelection showing their Party and how long they've been in office.
| State | Name | Party | Years in Office | Notes |
|---|---|---|---|---|
| Alabama | Doug Jones | Democratic | 3 | Incumbent renominated. |
| Alaska | Dan Sullivan | Republican | 6 | Incumbent renominated. |
| Arkansas | Tom Cotton | Republican | 6 | Incumbent renominated. |
| Colorado | Cory Gardner | Republican | 6 | Incumbent renominated. |
| Delaware | Chris Coons | Democratic | 10 | Incumbent renominated. |
| Georgia | David Perdue | Republican | 6 | Incumbent renominated. |
| Idaho | Jim Risch | Republican | 12 | Incumbent renominated. |
| Illinois | Dick Durbin | Democratic | 24 | Incumbent renominated. |
| Iowa | Joni Ernst | Republican | 6 | Incumbent renominated. |
| Kansas | Pat Roberts | Republican | 24 | Incumbent retiring. |
| Kentucky | Mitch McConnell | Republican | 36 | Incumbent renominated. |
| Louisiana | Bill Cassidy | Republican | 6 | Incumbent running. |
| Maine | Susan Collins | Republican | 24 | Incumbent renominated. |
| Massachusetts | Ed Markey | Democratic | 7 | Incumbent renominated. |
| Michigan | Gary Peters | Democratic | 6 | Incumbent renominated. |
| Minnesota | Tina Smith | Democratic | 2 | Incumbent renominated. |
| Mississippi | Cindy Hyde-Smith | Republican | 2 | Incumbent renominated. |
| Montana | Steve Daines | Republican | 6 | Incumbent renominated. |
| Nebraska | Ben Sasse | Republican | 6 | Incumbent renominated. |
| New Hampshire | Jeanne Shaheen | Democratic | 12 | Incumbent renominated. |
| New Jersey | Cory Booker | Democratic | 7 | Incumbent renominated. |
| New Mexico | Tom Udall | Democratic | 12 | Incumbent retiring. |
| North Carolina | Thom Tillis | Republican | 6 | Incumbent renominated. |
| Oklahoma | Jim Inhofe | Republican | 26 | Incumbent renominated. |
| Oregon | Jeff Merkley | Democratic | 12 | Incumbent renominated. |
| Rhode Island | Jack Reed | Democratic | 24 | Incumbent renominated. |
| South Carolina | Lindsey Graham | Republican | 18 | Incumbent renominated. |
| South Dakota | Mike Rounds | Republican | 6 | Incumbent renominated. |
| Tennessee | Lamar Alexander | Republican | 18 | Incumbent retiring. |
| Texas | John Cornyn | Republican | 18 | Incumbent renominated. |
| Virginia | Mark Warner | Democratic | 12 | Incumbent renominated. |
| West Virginia | Shelley Moore Capito | Republican | 6 | Incumbent renominated. |
| Wyoming | Mike Enzi | Republican | 24 | Incumbent retiring. |